Tumor-like Demyelination. Differentiation from Toxoplasmosis

Toxoplasmosis Immunohistochemistry

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Toxoplasma tachyzoites are stained in dark brown with anti-toxoplasma antibody. Macrophages contain granular material.  A cyst full of toxoplasma organisms stains darkly (arrow).   From Ellison D,* with permission.   A similar preparation would be negative in tumor-like demyelination.